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KMID : 0615720150320010097
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 1 p.97 ~ p.107
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The Antitumor Mechanism and Effects of Tetrodotoxin: a Literature Review
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Jo Ye-Eun
Lee Seung-Min
Yoon Kang-Hyun
Lim Ji-Seok
Lee Seung-Hoon
Choi Do-Young
Lee Jae-Dong
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Abstract
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Objectives: The purpose of this study is to explore the antitumor mechanism and effects of tetrodotoxin through a literature review of experimental and clinical studies.
Methods: Medical databases, including The Cochrane Library, Pubmed, NDSL, RISS4u and National Assembly Library, were searched for relevant articles published from January 1, 2000 to October 31, 2014 using the keywords ‘tetrodotoxin’, ‘cancer’ and ‘tumor’. The results were classified into experimental studies(in vitro and in vivo) and clinical studies. Analysis of the results was conducted on several research areas including the mechanism, antitumor effect and adverse effects of tetrodotoxin(TTX).
Results: A total of 34 experimental studies(32 in vitro and 2 in vivo) and 3 clinical studies were found in the search. Most of the experimental studies suggested blocking of voltage-gated sodium channels in metastasis of tumor cells as the main antitumor mechanism of TTX. The most common type of cancers mentioned in the experimental studies were prostate and breast cancer. All of the clinical studies were on the application of TTX on moderate to severe cancer-related pain. No adverse effects of TTX were reported in in vivo studies but mild to moderate adverse events were reported in clinical studies.
Conclusions: The results show that tetrodotoxin, which is the main component of Tetraodontidae(commonly known as pufferfish) poison, could be clinically used for antitumor therapy. However, further studies should be conducted on its safety.
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KEYWORD
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Tetrodotoxin, Tetraodontidae, Pufferfish, Antitumor, Mechanism
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